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CGRP (human), [125I]-, 10µCi

Calcitonin gene-related peptide (CGRP), labeled with 125I. CGRP binds calcitonin receptors.

For research use only. Not for use in diagnostic procedures
Product Variants
Part number: NEX354010UC
Unit Size: 10 µCi
List price: USD 2,314.00
Your price:
USD 2,314.00
USD 2,314.00 /each
Part number: NEX354050UC
Unit Size: 50 µCi
List price: USD 10,990.00
Your price:
USD 0.00
USD 10,990.00 /each

Overview

10 µCiQuantities of CGRP (human), [125I]- are available for your research.

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX354:

  1. Meens, M., Mattheij, N., van Loenen, P., Spijkers, L., Lemkens, P., Nelissen, J., Compeer, M., Alewijnse, A. and De Mey, J. (2012), G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide. British Journal of Pharmacology, 166: 297–308.
  2. Moore, E.L., Gingell, J.J., Kane, S.A., Hay, D.L., Salvatore, C.A. (2010), Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding. Biochem Biophys Res Commun, 394 (1): 141-145.

Specifications

Molecular Weight
3912
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Fresh Lot Days
Third Monday of each month
Label Position
Nominally Labeled
Radionuclide
125I
Radioisotope
I-125
Receptor Type
Calcitonin
Species
Human
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
Diabetes
Gastrointestinal
Unit Size
10 µCi

Resources

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Calendar
2024 Fresh Lot Calendar
Guide
Iodine-125 handling precautions

This document contains general information designed to provide a basic understanding of radiation safety for Iodine-125. While we...

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SDS, COAs, Manuals and more

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