What is the best time to screen for congenital hypothyroidism?

Neonatal screening programs differ from one another in the type of specimen required. In the United States, the recommendation is that a blood spot be collected by heel prick and spotted onto filter paper. It is highly desirable that the blood be collected when the infant is between 2–4 days of age (American Academy of Pediatrics (2006)), but in some screening programs the timing and number of specimens may be different. Consult local regulations for appropriate timing and screening specimen collection.

Which conditions does the TSH screening test cover?

GSP Neonatal hTSH kit is intended for the quantitative determination of human thyroid stimulating hormone (hTSH) in blood specimens dried on filter paper as an aid in screening newborns for congenital (neonatal) hypothyroidism using the GSP® instrument.

What is the difference between TSH and T4 newborn screening tests?

Both analytes are used in screening newborns for congenital hypothyroidism. TSH is produced by the pituitary gland and stimulates the thyroid gland to produce T4, which is the main thyroid hormone responsible for metabolism, growth, and neurodevelopment.

How does the hTSH screening kit support high-throughput laboratory workflows?

GSP Neonatal hTSH kit is intended to use with the GSP® instrument which is fully automated, high throughput analyzer for time-resolved and prompt fluorescence analysis of dried blood spot samples.

What is the best time to screen for congenital hypothyroidism?

Neonatal screening programs differ from one another in the type of specimen required. In the United States, the recommendation is that a blood spot be collected by heel prick and spotted onto filter paper. It is highly desirable that the blood be collected when the infant is between 2–4 days of age (American Academy of Pediatrics (2006)), but in some screening programs the timing and number of specimens may be different. Consult local regulations for appropriate timing and screening specimen collection.

Which conditions does the TSH screening test cover?

GSP Neonatal hTSH kit is intended for the quantitative determination of human thyroid stimulating hormone (hTSH) in blood specimens dried on filter paper as an aid in screening newborns for congenital (neonatal) hypothyroidism using the GSP® instrument.

What is the difference between TSH and T4 newborn screening tests?

Both analytes are used in screening newborns for congenital hypothyroidism. TSH is produced by the pituitary gland and stimulates the thyroid gland to produce T4, which is the main thyroid hormone responsible for metabolism, growth, and neurodevelopment.

How does the hTSH screening kit support high-throughput laboratory workflows?

GSP Neonatal hTSH kit is intended to use with the GSP® instrument which is fully automated, high throughput analyzer for time-resolved and prompt fluorescence analysis of dried blood spot samples.

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GSP Neonatal hTSH kit

The Revvity GSP® Neonatal hTSH kit is a fluorescent immunoassay designed for the determination of human thyroid-stimulating hormone (hTSH) in dried blood spot (DBS) specimens. The assay is intended for newborn screening programs to aid in the early detection and diagnosis of congenital hypothyroidism (CH), a common endocrine disorder that can lead to developmental delays if left untreated.

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Feature	Specification
Application	Newborn Screening

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Unit Size: 1 kit

Part #:

3301-001U

For in vitro diagnostic use. This product is only available where licensed in accordance with law. Please contact your local representative for availability.

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Product information

Overview

Congenital hypothyroidism (CH) results from a failure of the thyroid glands to produce thyroid hormones in adequate amounts. The condition can easily be treated with daily doses of thyroid hormones but clinical diagnosis is difficult to establish and the disease may continue unrecognized for a long time causing irreversible brain damage. However, increased thyroid stimulating hormone (hTSH) and decreased thyroxine are clear signs of CH, which have led to the establishment of large scale screening programs.

GSP Neonatal hTSH assay:

The incubation time is only 3.5 h
Sensitive, robust DELFIA chemistry for confidence in results
All reagents are ready to use
The kit contains reagents and plates for 1152 tests (12 plates)

The assay is based on a direct sandwich technique where two monoclonal antibodies recognize separate antigenic determinants on the hTSH molecule. The fluorescence signal is proportional to the analyte concentration in the sample.

Features/benefits:

The incubation time is only 3.5 h
Sensitive, robust DELFIA chemistry for confidence in results
All reagents are ready to use
The kit contains reagents and plates for 1152 tests (12 plates)

Specifications

Other specifications

Application	Newborn Screening
Brand	GSP®
Detection Modality	Time-Resolved Fluorescence (TRF)
Disorders	Congenital Hypothyroidism
Instrument Compatibility	GSP
Quantity	1152 tests
Sample Type	Dried blood spots
Technology	DELFIA
Unit Size	1 kit

FAQs

What is the best time to screen for congenital hypothyroidism?

Neonatal screening programs differ from one another in the type of specimen required. In the United States, the recommendation is that a blood spot be collected by heel prick and spotted onto filter paper. It is highly desirable that the blood be collected when the infant is between 2–4 days of age (American Academy of Pediatrics (2006)), but in some screening programs the timing and number of specimens may be different. Consult local regulations for appropriate timing and screening specimen collection.
Which conditions does the TSH screening test cover?

GSP Neonatal hTSH kit is intended for the quantitative determination of human thyroid stimulating hormone (hTSH) in blood specimens dried on filter paper as an aid in screening newborns for congenital (neonatal) hypothyroidism using the GSP® instrument.
What is the difference between TSH and T4 newborn screening tests?

Both analytes are used in screening newborns for congenital hypothyroidism. TSH is produced by the pituitary gland and stimulates the thyroid gland to produce T4, which is the main thyroid hormone responsible for metabolism, growth, and neurodevelopment.
How does the hTSH screening kit support high-throughput laboratory workflows?

GSP Neonatal hTSH kit is intended to use with the GSP® instrument which is fully automated, high throughput analyzer for time-resolved and prompt fluorescence analysis of dried blood spot samples.