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WIN 35428, [N-Methyl-3H]-, 250µCi (9.25MBq)

WIN 35428 [(–)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane], tritiated on the N-methyl group. WIN 35428 acts as an antagonist at dopamine transporters (DATs).

For research use only. Not for use in diagnostic procedures

Product Variants
Part number: NET1033250UC
Unit Size: 250 µCi
List price: USD 4,010.00
Your price:
USD 4,010.00
USD 4,010.00 /each
Part number: NET1033001MC
Unit Size: 1 mCi
List price: USD 8,902.00
Your price:
USD 0.00
USD 8,902.00 /each

Overview

250 µCi quantity of WIN 35428, [N-Methyl-3H]-, is available for your research. WIN 35428 is a dopamine reuptake inhibitor, and is a stimulant drug. These transporters are potential drug targets for attention deficit hyperactivity disorder (ADHD), bipolar disorder, clinical depression, and alcohol addiction.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1033:

  1. Hong, W.C., Yano, H., Hiranita, T., Chin, F.T., McCurdy, C.R., Su, T., Amara, S.G., Katz, J.L., The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats. Journal Biological Chemistry, 2017, 292 (27): 11250-11261.
  2. Hong, W.C., and Amara, S.G., Membrane Cholesterol Modulates the Outward Facing Conformation of the Dopamine Transporter and Alters Cocaine Binding. Journal of Biological Chemistry, 2010, 285 (42): 32616-32626.

Specifications

Molecular Weight
277.3
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Label Position
Specifically Labeled
One Unit Contains
250.0 µCi
Radionuclide
3H
Radioisotope
H-3
Receptor Type
Dopamine
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
CNS & Neurologic
Unit Size
250 µCi

Resources

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