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U-69,593, [Phenyl-3,4-3H]-, 250µCi (9.25MBq)

U-69,593, tritiated at the phenyl-3,4 position. U-69,593 is a selective κ1-opioid receptor agonist.

For research use only. Not for use in diagnostic procedures

Part number: NET952250UC
List price: USD 3,968.00
Your price:
USD 3,968.00
USD 3,968.00 /each

Overview

U-69,593 acts as an agonist at kappa 1 opioid receptors (KORs). These receptors are a class of GPCRs involved in pain, consciousness, stress, and mood.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET952:

  1. Meng F, Xie GX, Thompson RC, Mansour A, Goldstein A, Watson SJ, and Akil H (1993) Cloning and pharmacological characterization of a rat kappa opioid receptor. Proc Natl Acad Sci USA 90:9954–9958.

Specifications

Molecular Weight
356.5
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Label Position
Specifically Labeled
One Unit Contains
250.0 µCi
Radionuclide
3H
Radioisotope
H-3
Receptor Type
Opioid
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
CNS & Neurologic
Inflammation
Pain
Unit Size
250 µCi

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