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SR141716A, [3H]

Tritiated SR141716A (rimonabant; Acomplia; Zimulti). SR141716A acts as an inverse agonist at the cannabinoid CB1 receptor.

For research use only. Not for use in diagnostic procedures
Part number: NET1158250UC
List price: USD 4,417.00
Your price:
USD 4,417.00
USD 4,417.00 /each

Overview

SR141716A acts as an antagonist at the cannabinoid CB1 receptor, and is used to treat obesity. Cannabinoid receptors are a group of GPCRs that are potential drug targets for smoking sessation and weight loss.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1158:

  1. Bisset, K.M., Dhopeshwarkar, A.S., Liao, C., Nicholson, R.A. (2011) The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: Inhibition by phthalate esters in vitro, Neurochemistry International, 59 (5): 706-713.
  2. Liao, C., Zheng, J., David, L. S. and Nicholson, R. A. (2004), Inhibition of Voltage-Sensitive Sodium Channels by the Cannabinoid 1 Receptor Antagonist AM 251 in Mammalian Brain. Basic & Clinical Pharmacology & Toxicology, 94: 73–78.

Specifications

Molecular Weight
463.79
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Label Position
Specifically Labeled
Radionuclide
3H
Radioisotope
H-3
Receptor Type
Cannabinoid
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
Angiogenesis
Cardiovascular
CNS & Neurologic
Gastrointestinal
Inflammation
Metabolic Disorders
Pain
Unit Size
250 µCi

Resources

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