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Ro 15-1788, [N-Methyl-3H]-, 1 mCi

Ro 15-1788 (flumazenil), tritiated on the N-methyl group. Ro 15-1788 acts as a selective benzodiazepine antagonist.

For research use only. Not for use in diagnostic procedures
Part Number: NET757250UC
Unit Size: 250 µCi
Part Number: NET757001MC
Unit Size: 1 mCi
  • 1 mCi quantities of Ro 15-1788, [N-Methyl-3H]-, are available for research. Ro 15-1788 acts as a selective benzodiazepine antagonist. It is used to treat benzodiazepine overdoses and reverse anesthesia.

    We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

    Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

    References for NET757:

    1. Benke D, Cicin-Sain A, Mertens S, Mohler H. Immunochemical identification of the alpha 1- and alpha 3-subunits of the GABAA-receptor in rat brain. J Recept Res. 1991;11(1-4):407-24.
    2. Goeders, N., Kuhar, M.J. Benzodiazepine receptor binding invivo with [3H]-Ro 15-1788, Life Sciences, Volume 37, Issue 4, 1985, Pages 345-355.
  • Molecular Weight
    303
    Brand
    NEN Radiochemicals
    Detection Method
    Radiometric
    Label Position
    Specifically Labeled
    Radioisotope
    H-3
    Receptor Type
    Benzodiazepine
    GABAA
    Shipping Conditions
    Shipped in Dry Ice
    Special Ordering Information
    This is a radioactive product - shipping address must have a license to receive radioactive materials.
    Unit Size
    1 mCi

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