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IVISense Neutrophil Elastase 680 FAST Fluorescent Probe
IVISense Neutrophil Elastase 680 FAST Fluorescent Probe
IVISense™ fluorescent imaging probes - optimized and validated on Revvity's IVIS® optical imaging platform
IVISense™ Neutrophil Elastase 680 FAST is a NIR fluorescent probe designed to detect neutrophil elastase (NE) activity in vivo. It enables visualization of NE released during neutrophil activation via degranulation or netosis.
NE is a protease secreted by neutrophils - first-line defenders of the innate immune system. While traditionally viewed as indiscriminate killers, neutrophils are now known to contribute to chronic inflammation and tissue repair.
| Feature | Specification |
|---|---|
| Unit Size | 1 vial (10 doses) |
| Specificity | Neutrophil Elastase |
IVISense™ Neutrophil Elastase 680 FAST is a NIR fluorescent probe designed to detect neutrophil elastase (NE) activity in vivo. It enables visualization of NE released during neutrophil activation via degranulation or netosis.
NE is a protease secreted by neutrophils - first-line defenders of the innate immune system. While traditionally viewed as indiscriminate killers, neutrophils are now known to contribute to chronic inflammation and tissue repair.
Product variant
Wave Length: 680 nm
Part #:
NEV11169
List price
USD 700.00
Your online price:
For research use only. Not for use in diagnostic procedures.
IVISense Neutrophil Elastase 680 FAST Fluorescent Probe
IVISense™ fluorescent imaging probes - optimized and validated on Revvity's IVIS® optical imaging platform
IVISense Neutrophil Elastase 680 FAST Fluorescent Probe
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Product information
Overview
IVISense Neutrophil Elastase 680 FAST™ is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with a broader range of early imaging time points. This architecture also offers higher target specific signal with reduced background.
This NIR agent is a neutrophil elastase activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by elastase produced by neutrophil cells. Neutrophil elastase is a key protease involved in acute lung injury, acute respiratory distress syndrome, as well as many other inflammatory processes such as emphysema, cystic fibrosis, COPD, wound healing, rheumatoid arthritis, ischemia-reperfusion and many others.
IVISense Neutrophil Elastase 680 FAST fluorescent imaging agent is a selective neutrophil elastase-activatable agent designed for imaging of this serine protease both in vitro and in vivo. The half-life in plasma of Neutrophil Elastase 680 FAST is 4 hours.
Specifications
| Brand |
IVISense
|
|---|---|
| Fluorescent Agent Type |
Enzyme activated
|
| Imaging Modality |
Fluorescence
|
| Shipping Conditions |
Shipped in Blue Ice
|
| Specificity |
Neutrophil Elastase
|
| Storage Conditions |
-30 to -16 °C
|
| Therapeutic Area |
Inflammation
|
| Unit Size |
1 vial (10 doses)
|
| Wave Length |
680 nm
|
Resources
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Whitepaper
Understanding the ‘how’ and ‘why’ of spectral unmixing
In vivo fluorescence imaging displays a very broad utility and has become a well-established modality for functional imaging in...
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