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Insulin (porcine), Receptor Grade, [125I]TyrA14, 10µCi

Porcine insulin, labeled with 125I on tyrosineA14. This product is receptor-grade, and was developed for receptor-binding assays. Insulin binds and activates insulin receptor (IR), a tyrosine kinase receptor involved in glucose uptake.

For research use only. Not for use in diagnostic procedures
Product Variants
Part number: NEX196010UC
Unit Size: 10 µCi
List price: USD 2,075.00
Your price:
USD 2,075.00
USD 2,075.00 /each
Part number: NEX196050UC
Unit Size: 50 µCi
List price: USD 8,023.00
Your price:
USD 0.00
USD 8,023.00 /each

Overview

10 µCiQuantities of Insulin (porcine), Receptor Grade, [125I]TyrA14are available for your research.

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX196:

  1. Goustin, A., Derar, N., Abou-Samra, A., (2013), Ahsg-fetuin blocks the metabolic arm of insulin action through its interaction with the 95-kD β-subunit of the insulin receptor, Cellular Signalling, 25 (4): 981-988.
  2. Chen, L., Yao, X.H., Nyomba, B.L. (2005) In vivo insulin signaling through PI3-kinase is impaired in skeletal muscle of adult rat offspring exposed to ethanol in utero. J Appl Physiol, 99 (2): 528-534.

Specifications

Concentration
79.20 µCi/mL
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Fresh Lot Days
Fourth Monday of each month
Label Position
Nominally Labeled
Radionuclide
125I
Radioisotope
I-125
Receptor Type
Insulin
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
Diabetes
Obesity
Unit Size
10 µCi

Resources

1-2 of 2 Resources
Calendar
2024 Fresh Lot Calendar
Guide
Iodine-125 handling precautions

This document contains general information designed to provide a basic understanding of radiation safety for Iodine-125. While we...

SDS, COAs, Manuals and more Illuminator

SDS, COAs, Manuals and more

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