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Hydroxytryptamine Creatinine Sulfate (Serotonin), 5-[1,2-3H(N)]-, 1mCi (37MBq)

5-Hydroxytryptamine Creatinine Sulfate (Serotonin, 5-HT), tritiated at the 1,2 position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors.

For research use only. Not for use in diagnostic procedures

Product Variants
Part number: NET498001MC
Unit Size: 1 mCi
List price: USD 1,607.00
Your price:
USD 1,607.00
USD 1,607.00 /each
Part number: NET498005MC
Unit Size: 5 mCi
List price: USD 7,144.00
Your price:
USD 0.00
USD 7,144.00 /each

Overview

1 mCi quantities of Hydroxytryptamine Creatinine Sulfate (Serotonin), 5-[1,2-3H(N)]-, are available for your research. 5-Hydroxytryptamine (5-HT) binds and activates 5-HT (serotonin) receptors. These receptors are a group of GPCR and ligand-gated ion channels found in the peripheral and central nervous system, and are involved in anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET498:

  1. Simmler, L. D., Anacker, A. M. J., Levin, M. H., Vaswani, N. M., Gresch, P. J., Nackenoff, A. G., Anastasio, N. C., Stutz, S. J., Cunningham, K. A., Wang, J., Zhang, B., Henry, L. K., Stewart, A., Veenstra-VanderWeele, J., and Blakely, R. D. (2017) Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. British Journal of Pharmacology, 174: 2716–2738.
  2. Kawai, M., Goda, R., Otsuka, T., Iwamoto, A., Uotsu, N., Furuse, M., Yasuo, S. (2015) Antidepressant-like effect of bright light is potentiated by l-serine administration in a mouse model of seasonal affective disorder, Brain Research Bulletin, Volume 118: 25-33.
  3. Cui XF, Zhou WM, Yang Y, Zhou J, Li XL, Lin L, Zhang HJ. (2014) Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome. World J Gastroenterol. 20:13521–13529.

Specifications

Molecular Weight
387.4
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Label Position
Nominally Labeled
Radionuclide
3H
Radioisotope
H-3
Receptor Type
5-Hydroxytryptamine
Shipping Conditions
Shipped in Blue Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
Cardiovascular
CNS & Neurologic
Gastrointestinal
Inflammation
Metabolic Disorders
Unit Size
1 mCi

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