Skip to main content
Menu
US

Hemicholinium-3 Diacetate Salt, [Methyl-3H]-, 250µCi (9.25MBq)

Hemicholinium-3 (HC3; hemicholine) Diacetate Salt, tritiated on the methyl group. Hemicholinium-3 blocks reuptake of choline by the high-affinity choline transporter.

For research use only. Not for use in diagnostic procedures.

Click to copy promo code to clipboard.
SAVE 15% NOW on online orders. Use promo code below.
YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Feature Specification
Concentration 1 mCi/ml
Label Position Specifically Labeled
Molecular Weight 532.6
Receptor Acetylcholine

Hemicholinium-3 (HC3; hemicholine) Diacetate Salt, tritiated on the methyl group. Hemicholinium-3 blocks reuptake of choline by the high-affinity choline transporter.

For research use only. Not for use in diagnostic procedures.

Click to copy promo code to clipboard.
SAVE 15% NOW on online orders. Use promo code below.
YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Product Variant
Unit Size: 250 µCi
Part #:
NET884250UC
List Price
USD 13,520.00

Overview

Hemicholinium-3 is an inhibitor that blocks reuptake of choline by the high-affinity choline transporter. This transporter mediates drug delivery across the blood-brain barrier.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET884:

  1. Sekiguchi, K., Imamura, S., Yamaguchi, T., Tabuchi, M., Kanno, H., Terawaki, K., Kase, Y. and Ikarashi, Y. (2011), Effects of yokukansan and donepezil on learning disturbance and aggressiveness induced by intracerebroventricular injection of amyloid β protein in mice. Phytother. Res., 25: 501–507.
  2. Krištofiková, Z., Kopecký, V., Hofbauerová, K. et al. (2008) Complex of Amyloid β Peptides with 24-Hydroxycholesterol and Its Effect on Hemicholinium-3 Sensitive Carriers. Neurochem Res., 33: 412.

Specifications

Concentration
1 mCi/ml
Molecular Weight
532.6
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer/Solvent
Ethanol
Detection Modality
Radiometric
Label Position
Specifically Labeled
Packaging
NENSure vial
Radioisotope
3H
Receptor
Acetylcholine
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
-80°C
Therapeutic Area
Cardiovascular
CNS & Neurologic
Gastrointestinal
Unit Size
250 µCi

Resources

Are you looking for resources, click on the resource type to explore further.

1-2 of 2 Resources
Product Info Icon
Product Info
Calendar: NEN® Radiochemicals 2024 Fresh Lot
Flyer Icon
Flyer
NENSure: The safest packaging for radiochemicals
Scroll Icon