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GSP Neonatal Phenylalanine kit

Phenylketonuria (PKU) is a disorder of amino acid metabolism with reported incidence ranging from 1 in 19,000 to 1 in 13,500 newborn infants*. It is caused by an inability to convert phenylalanine to tyrosine due to deficient activity of the enzyme, phenylalanine hydroxylase.

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Part Number: 3308-0010
  • As a result, excessive amounts of phenylalanine and toxic metabolites accumulate, harming brain development. The symptoms can be clearly reduced with a diet low in phenylalanine, and early detection is critical in starting the treatment and ensuring normal brain development.

    * Kaye CI. and the Committee on Genetics (2006) Newborn Screening Fact Sheets. Pediatrics 118 (3).

    GSP Neonatal Phenylalanine - the automated enzymatic assay

    The GSP Neonatal Phenylalanine (Phe) kit is intended for the quantitative determination of phenylalanine concentrations in blood specimens dried on filter paper as an aid in screening newborns for phenylketonuria by using the GSP® instrument.

    • Automated assay
    • Incubation time only 2 x 1h
    • Improved precision and performance compared to manual assays
    • Contains reagents for 1152 tests (12 plates), clear microplates, U-bottomed, should be ordered separately in a bulk pack of 100.
    • 5760 tests (60 plates) product version also available (product no 3308-001B)
    • Calibrators and controls are in cassette format
  • Application
    Newborn Screening
    Assay Technology
    Enzymatic
    Calibration Standards
    Yes
    Detection Method
    Enzymatic
    Disorders
    Phenylketonuria
    Sample Type
    Dried blood spots
    Brand
    GSP®