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Ghrelin (human), [His[125I]], 10µCi

Ghrelin, labeled with 125I. Ghrelin is a peptide that regulates appetite and energy, and binds the ghrelin/growth hormone secretagogue receptor (GHS-R).

For research use only. Not for use in diagnostic procedures.

Product Variants
Part number: NEX388010UC
Unit Size: 10 µCi
List price: USD 2,427.00
Your price: Login to view
USD 2,427.00
USD 2,427.00 /each
Part number: NEX388025UC
Unit Size: 25 µCi
List price: USD 4,728.00
Your price: Login to view
USD 0.00
USD 4,728.00 /each

Overview

10 µCiQuantities of Ghrelin (human), [His[125I]] are available for your research.

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX388:

  1. Gauna, C., van de Zande, B., van Kerkwijk, A., Themmen, A.P., van der Lely, A.J., Delhanty, P.J. (2007), Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R). Mol Cell Endocrinol, 274 (1-2): 30-34.
  2. Leung, P.K., Chow, K.B., Lau, P.N., Chu, K.M., Chan, C.B., Cheng, C.H., Wise, H. (2007), The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor. Cell Signal, 19 (5): 1011-1022.

Specifications

Molecular Weight
3495
Specific Activity
2200.0 Ci/mmol
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer/Solvent
0.1% trifluroacetic acid and 0.4% BSA : 46% 1-propanol and 54% acetonitrile (1:1)
Detection Modality
Radiometric
Fresh Lot Days
Fourth Monday of each month
Host Species
Human
Label Position
Nominally Labeled
Packaging
NENSure vial
Radioisotope
125I
Receptor
Ghrelin
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
-20°C
Therapeutic Area
CNS & Neurologic
Obesity
Unit Size
10 µCi

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