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Ethylcarboxamidoadenosine, 5'-N-[Adenine-2,8-3H]-, 250µCi (9.25MBq)

5'-N-Ethylcarboxamidoadenosine (NECA), tritiated at the adenine-2,8 position. 5'-N-Ethylcarboxamidoadenosine is an adenosine analog that acts as an agonist at adenosine receptors A1, A2A, and A3.

For research use only. Not for use in diagnostic procedures

Part number: NET811250UC
List price: USD 2,858.00
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USD 2,858.00
USD 2,858.00 /each

Overview

5'-N-Ethylcarboxamidoadenosine acts as an agonist at adenosine receptors, and is a vasodilator. Adenosine receptors are a group of GPCRs that play a role in blood flow.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET811:

  1. G S Firestein, D A Bullough, M D Erion, R Jimenez, M Ramirez-Weinhouse, J Barankiewicz, C W Smith, H E Gruber, K M Mullane. Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins. The Journal of Immunology January 1, 1995, 154 (1) 326-334.

Specifications

Molecular Weight
308.28
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Detection Method
Radiometric
Label Position
Specifically Labeled
One Unit Contains
250.0 µCi
Radioisotope
3H
Receptor Type
Adenosine
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
Cardiovascular
CNS & Neurologic
Inflammation
Metabolic Disorders
Unit Size
250 µCi

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