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Dihydroxyphenylethylamine, 3,4-[7-3H]-, 250µCi (9.25MBq)

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the 7 position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors.

For research use only. Not for use in diagnostic procedures.

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Feature Specification
Concentration 1 mCi/mL
Label Position Specifically Labeled
Molecular Weight 153.2
Receptor Dopamine

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the 7 position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors.

For research use only. Not for use in diagnostic procedures.

Click to copy promo code to clipboard.
SAVE 15% NOW on online orders. Use promo code below.
YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Product Variants
Unit Size: 250 µCi
Part #:
NET131250UC
List Price
USD 1,933.00
Unit Size: 1 mCi
Part #:
NET131001MC
List Price
USD 5,825.00

Overview

250 µCi quantity of Dihydroxyphenylethylamine, 3,4-[7-3H]-, is available for your research. Dihydroxyphenylethylamine binds dopamine receptors, a class of GPCRs in the central nervous system. Dopamine receptors are implicated in motivation, pleasure, cognition, memory, and learning and are potential drug targets for schizophrenia, Parkinson's disease, and a variety of other psychiatric and neurological conditions.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET131:

  1. Oaks AW, Frankfurt M, Finkelstein DI, Sidhu A (2013) Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function. PLoS ONE 8(4): e60378.
  2. Oaks AW, Marsh-Armstrong N, Jones JM, Credle JJ, Sidhu A (2013) Synucleins Antagonize Endoplasmic Reticulum Function to Modulate Dopamine Transporter Trafficking. PLoS ONE 8(8): e70872.

Specifications

Concentration
1 mCi/mL
Molecular Weight
153.2
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer/Solvent
0.2N acetic acid : ethanol (9:1)
Detection Modality
Radiometric
Label Position
Specifically Labeled
Packaging
NENSure vial
Radioisotope
3H
Receptor
Dopamine
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
5°C
Therapeutic Area
CNS & Neurologic
Unit Size
250 µCi

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