How does the LabChip system work?
The LabChip GX Touch and GXII Touch systems use microfluidic technology to automate separation, sizing, and quantitation on a single chip. These micro-CE platforms support high-resolution, digital data from 96- or 384-well plates in seconds.
- Multi-Analyte Flexibility: separate proteins, glycans, AAVs, DNA, or RNA fragments with sharp band resolution across genomics and proteomics workflows.
- Picogram-level sensitivity: laser-induced fluorescence detects low concentrations down to 10 pg/µL for DNA/proteins and 1 pg/µL for RNA fragments.
- Automated data processing: automatically size and quantify fragments against internal markers and calibration ladders.
- Instant digital insights: provide immediate data visualization through automated electropherograms, virtual gels, and exportable tabular reports.
- High-Throughput Speed: process samples in as little as 30 to 65 seconds directly from plates, reducing hands-on sample preparation time.
LabChip GX/GXII Empower software driver
Accelerate your biotherapeutic characterization with LabChip microfluidic capillary electrophoresis (micro-CE), featuring direct, driver-based integration into your Waters™ Empower™ CDS platform.
- Direct software integration: Run your LabChip system natively inside the Waters™ Empower™ CDS without external interface dependencies.
- Flexible and extended assay protocols: Setup advanced LabChip micro-CE protocols, including sip replicates and ladder bracketing, within the Empower Method Editor.
- Automated data flow: Removes the need for manual file conversions reducing potential transcription errors.
- Compliance and audit readiness: Your LabChip micro-CE data innately inherits the Waters™ Empower™’s electronic records, robust system audit trails, and strict risk-based user access controls, making it well-suited for QA/QC labs in GxP-regulated environments.
Customer experience
At our recent Advanced Biotherapeutic Summit, leading scientists from across the industry and academia, including Covaris, Evonik, Kytopen, ModeX Therapeutics, Tiba Biotech, and the Whitehead Institute, shared how they leverage LabChip technology to accelerate next-generation therapies.
Discover how our user community applies microfluidic capillary electrophoresis to streamline development and optimize workflows:
- mRNA Vaccine & Cell Therapy Optimization Researchers demonstrated how they streamline mRNA integrity and stability testing for preclinical vaccines, alongside rapid, high-throughput nonviral cell therapy optimization.
- Advanced Biologics Characterization Industry experts shared protocols for performing precision sizing and N-glycan analysis of antibody molecules with complex post-translational modifications (PTMs).
- Head-to-Head Instrument Benchmarking Speakers presented comparative data evaluating the LabChip GX Touch-HT against three competitor platforms for fragmented nucleic acid analysis.
- Cell Culture & Platform Performance Presentations highlighted methods for characterizing cell culture medium supplements and optimizing protein expression platforms to improve both yield and quality.
Choosing your LabChip instrument
| Feature / Metric | LabChip GX Touch 24 | LabChip GX Touch HT | LabChip GXII Touch HT |
|---|---|---|---|
| Primary Domain | Genomics | Genomics | Proteomics & Genomics |
| Application Suitability | Small-scale R&D labs, targeted PCR assays, localized cloning QC. | High-throughput sequencing cores, large-scale NGS library preparation libraries. | Biotherapeutic development (mAbs), cell & gene therapy (AAV), protein engineering. |
| Maximum Sample Capacity | Up to 48 samples per run | Up to 384 samples per run | Up to 384 samples per run |
| Minimum Sample Volume |
2 µL (conserves precious sample) |
2 µL (Genomics) / 2 µL (Protein preparation) | |
| Separation Runtime / sample |
DNA: ~28–188 sec RNA: ~80 sec |
Protein: ~41–100 sec DNA: ~28-188 sec RNA: ~80 sec |
|
| Analytical Sensitivity (LOD) |
DNA: Down to 2 pg/µL RNA (Pico): 250 pg/µL |
Protein (Pico): 10 pg/µL Protein (Clear HR): 5 ng/µL (mAb) |
|
| Unique Algorithmic Metrics |
RNA Quality Score (RQS) DNA Quality Score (DQS) |
RNA Quality Score (RQS) DNA Quality Score (DQS) |
|
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