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CGS 21680, [Carboxyethyl-3H(N)]-, 1mCi (37MBq)

CGS 21680, tritiated at the carboxyethyl group. CGS 21680 acts as an agonist for the adenosine A2A receptor, but can also bind adenosine A1 and A3.

For research use only. Not for use in diagnostic procedures.

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Feature Specification
Concentration 1 mCi/ml
Label Position Nominally Labeled
Molecular Weight 499.53
Receptor Adenosine

CGS 21680, tritiated at the carboxyethyl group. CGS 21680 acts as an agonist for the adenosine A2A receptor, but can also bind adenosine A1 and A3.

For research use only. Not for use in diagnostic procedures.

Click to copy promo code to clipboard.
SAVE 15% NOW on online orders. Use promo code below.
YEAREND15
Offer valid until 12/15. Terms and conditions apply.
Product Variants
Unit Size: 250 µCi
Part #:
NET1021250UC
List Price
USD 3,289.00
Unit Size: 1 mCi
Part #:
NET1021001MC
List Price
USD 7,803.00

Overview

CGS 21680 is an agonist for the adenosine A2A receptor. Adenosine A2A receptors are GPCRs that regulate myocardial blood flow as well as glutamate and dopamine release in the brain. These receptors are potential drug targets for insomnia, pain, depression, drug addiction, and Parkinson's disease.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1021:

  1. Varani, K., Gessi, S., Dalpiaz, A. and Borea, P. A. (1996), Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding. British Journal of Pharmacology, 117: 1693–1701.
  2. Michael F. Jarvis, Michael Williams, Direct autoradiographic localization of adenosine A2 receptors in the rat brain using the A2-selective agonist, [3H]CGS 21680, In European Journal of Pharmacology, Volume 168, Issue 2, 1989, Pages 243-246.

Specifications

Concentration
1 mCi/ml
Molecular Weight
499.53
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer/Solvent
70% Ethanol
Detection Modality
Radiometric
Label Position
Nominally Labeled
Packaging
NENSure vial
Radioisotope
3H
Receptor
Adenosine
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
-20°C
Therapeutic Area
Cardiovascular
CNS & Neurologic
Inflammation
Metabolic Disorders
Unit Size
1 mCi

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