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5-CT, [3H]

5-carboxyamidotryptamine (5-CT) labeled with tritium. 5-CT is a tryptamine derivative closely related to the neurotransmitter serotonin. 5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 serotonin receptors. It also binds the 5-HT2, 5-HT3, 5-HT6 serotonin receptors with lower affinity.

For research use only. Not for use in diagnostic procedures

Part number: NET1188U100UC
List price: USD 4,338.00
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USD 4,338.00
USD 4,338.00 /each

Overview

5-CT is a tryptamine derivative closely related to serotonin. 5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as at the 5-HT2, 5-HT3, 5-HT6 receptors with lower affinity. These receptors are part of a group of serotonin G-protein coupled receptors (GPCRs) found in the central and peripheral nervous systems, and modulate the release of neurotransmitters and hormones. 5-HT receptors are the pharmacological target of many antidepressants, antipsychotic, anti-migraine, and other pharmaceutical drugs.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1188:

  1. G. Satała, B. Duszyńska, T. Lenda, G. Nowak, A. J. Bojarski. Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions, Molecular Neurobiology, 2017, pages 1-14.
  2. K.W. Andressen, A. H. Ulsund, K. A. Krobert, M. J. Lohse, M. Bünemann, F. O. Levy, Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation, FASEB, 2017.

Specifications

Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Label Position
Generally Labeled
One Unit Contains
100.0 µCi
Radioisotope
3H
Receptor Type
5-Hydroxytryptamine
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area
CNS & Neurologic
Unit Size
100 µCi

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